University of Lethbridge Team Wins Silver at International iGEM

The University of Lethbridge (U of L) secured a silver medal at the 2025 Grand Jamboree held in Paris, recognizing the innovative work of a student team in the International Genetically Engineered Machine (iGEM) competition. Originally aimed at developing an efficient and ethical method for producing hyaluronic acid for the cosmetics industry, the project evolved into a significant engineering accomplishment with broader implications for genetic research.

Initially, the U of L team, consisting of 16 students and supervised by Dr. Laura Keffer-Wilkes, sought to create a method for producing hyaluronic acid using E. coli. As the project progressed, they faced a significant challenge: the need for a multiplex automated genome engineering (MAGE) machine, which costs around $90,000. Realizing that such funds were unattainable, the students pivoted their focus to developing an open-source alternative.

The result was OSAGE, or open-source automated genome engineering, a cost-effective solution that can be constructed for under $1,000. “We needed a way to make the hyaluronic acid, and we wanted to use E. coli by mixing genes into its plasmid to spur the production of a hyaluronic acid biofilm,” said Abby Giacchetta, a third-year neuroscience student and team member. The OSAGE machine utilizes affordable, readily available components sourced online, along with 3D-printed parts, making it accessible for future projects.

Building on the collaborative ethos of the iGEM community, the U of L students drew inspiration from previous iGEM projects to enhance their design. “One of the great things about iGEM is that it is open source, meaning everyone has access to all the great work that’s been done in previous years,” Dr. Keffer-Wilkes noted. The team’s approach not only addressed their immediate needs but also established a foundation for future iGEM participants to engineer various bacterial strains.

The judges at the Grand Jamboree recognized the potential impact of OSAGE, awarding the U of L team a silver medal. Many praised the initiative for building upon the work of past teams, reinforcing the collaborative spirit of scientific advancement.

Looking ahead, the team aims to expand its membership, encouraging students from various fields to contribute to their ongoing research. Applications for the 2026 iGEM cycle are currently open, inviting interested candidates to visit the iGEM webpage or contact Dr. Keffer-Wilkes at [email protected].

This achievement not only highlights the innovative spirit of the University of Lethbridge but also underscores the importance of accessible scientific tools in advancing genetic engineering research for future generations.